|Curiosity leads human to various inventions to solve problems and cures too many diseases. Autism Spectrum Disorder (ASD) is such a term that there are many researches enduring like Magnetic Resonance Imaging (MRI), called diffusion tensor imaging, Early Start Denver Model (ESDM) to provide an easier life. After years and years of combined funding sources from public and private funding, these researches show great promises in recent years. In this paper we have tried to show a way how children with Down Syndrome Autism can learn through game therapy. These game therapies have shown an immense number of improvements among those children to learn alphabets along with developing their motor skills and memory challenges.